Identification and characterization of potential druggable targets among Essential Hypothetical Proteins of A. baumannii

Acinetobacter baumannii, a gram negative bacteria, has emerged as critical pathogen responsible for nosocomial and other infections. A. baumannii exhibits resistance to variety of antibiotic classes, emphasizing that new therapeutic targets are urgently needed. In ATCC 179778, 458 genes have been identified essential genes, indispensable growth survival the pathogen. The functions 47 proteins encoded by A.baumannii were found be hypothetical thus referred (EHPs). present study aims carry out functional characterization EHPs using bioinformatics tools/databases. Evaluation physicochemical parameters, homology search against known proteins, domain analysis, subcellular localization 3D structure prediction virulence assisted us characterize EHPs. They belong different classes like enzymes, binding helicases, transporters, miscellaneous factors. Around 47% enzymes. A group (17.6%) predicted Proteins in but absent host non-homology analysis. Further druggability analysis examined druggable property proteins. Of 34, 27 pathogen-specific which could serve potential novel drug vaccine targets. Druggability was performed One target others study's findings might assist development drugs treatment